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Systemic Immune Modulation by Stereotactic Radiotherapy in Early-stage Lung Cancer
Eleni Gkika
Elke Firat
Sonja Adebahr
Erika Graf
Ilinca Popp
Gianluca Radicioni
Simon S. Lo
Ursula Nestle
Nils Nicolay
Gabriele Niedermann
Dan G. Duda
Anca-Ligia Grosu
出版
Universität
, 2023
URL
http://books.google.com.hk/books?id=fznfzwEACAAJ&hl=&source=gbs_api
註釋
Abstract: We performed a prospective study of circulating immune cell changes after stereotactic body radiotherapy (SBRT) in 50 early-stage NSCLC patients. We found no significant increase in CD8+ cytotoxic T lymphocytes at first follow-up (the primary endpoint) but detected a significant increase in expanding Ki-67+CD8+ and Ki-67+CD4+ T-cell fractions in patients treated with 10 Gy or less per fraction. SBRT can induce significant expansion in circulating effector T-cells immediately post-treatment