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The Interplay Between Diet, Gastrointestinal Complaints and Gut Microbiota
其他書名
More Than a Gut Feeling?
出版Wageningen University, 2022
ISBN94644719059789464471908
URLhttp://books.google.com.hk/books?id=gFM_zwEACAAJ&hl=&source=gbs_api
註釋Next, a longitudinal study including two timepoints with 4 weeks in between was performed, which included 91 IBS patients and 30 matched controls (Chapter 3). This study investigated the dynamics of gut microbiota and SCFA levels in different IBS severity groups, and the association between stool pattern, diet, depression, anxiety and QoL over time. We observed large time-dynamics, as already 36% of the IBS patients changed severity group and 53% had a different stool pattern within 4 weeks of time. No consistent differences between IBS patients and controls or IBS severity groups were observed in microbial alpha diversity or composition, and SCFA levels. The relative abundance of Bifidobacterium was consistently lower in IBS compared to controls while that of Terrisporobacter and Turicibacter were higher. These genera could be potential targets for future microbiota-mediated treatment strategies in IBS. Importantly, Chapter 3 shows that longitudinal studies are crucial to discriminate consistent associations between different datasets from coincidental observations. Due to the large within-person variation over time, biological interpretation from cross-sectional studies is thus very limited and may partly explain the inconsistency between studies.