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Minced Cartilage is a One-step Cartilage Repair Procedure for Small Defects in the Knee - a Systematic-review and Meta-analysis

Andreas FrodlMarkus Alexander SiegelAndreas FuchsFerdinand Christian Ludwig WagnerHagen SchmalKaywan IzadpanahTayfun Yilmaz

出版	Universität, 2022
URL	http://books.google.com.hk/books?id=gc2azwEACAAJ&hl=&source=gbs_api

註釋Abstract: Purpose: Approximately 60% of patients undergoing arthroscopy of the knee present with chondral defects. If left untreated, osteochondral lesions can trigger an early onset of osteoarthritis. Many cartilage repair techniques are mainly differentiated in techniques aiming for bone marrow stimulation, or cell-based methods. Cartilage repair can also be categorized in one- and two-stage procedures. Some two-stage procedures come with a high cost for scaffolds, extensive cell-processing, strict regulatory requirements, and limited logistical availability. Minced cartilage, however, is a one-stage procedure delivering promising results in short term follow-up, as noted in recent investigations. However, there is no available literature summarizing or synthesizing clinical data. The purpose of this study was to analyze and synthesize data from the latest literature in a meta-analysis of outcomes after the minced cartilage procedure and to compare its effectiveness to standard repair techniques. Methods: We conducted a systematic review searching the Cochrane, PubMed, and Ovid databases. Inclusion criteria were the modified Coleman methodology Score (mCMS) >60, cartilaginous knee-joint defects, and adult patients. Patient age