The book compiles 19 authors who approach the 15 Global Challenges identified by the Millennium Project as the main threats and opportunities for the present Millennium as a methodological conceptual framework for Mexico's futures. The first part launches diagnoses that are formulated on each Challenge and visions and reflections are proposed. The second part presents three possible scenarios for Mexico by 2050 and, finally, it concludes with a proposal for guiding projects by 2050.