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Effects of Irradiation and Blast on Pulmonary Funcion in Sheep

John T. YelvertonDamon Edward G.Robert K. JonesThomas L. ChiffelleUlrich C. Luft

出版	Lovelace Foundation for Medical Education and Research, 1971
URL	http://books.google.com.hk/books?id=gfGuLa_kOjoC&hl=&source=gbs_api
EBook	FULL_PUBLIC_DOMAIN

註釋The changes in pulmonary function that result following unilateral exposure to LD50 doses of neutron-gamma irradiation and/or sublethal blast overpressures were investigated in sheep. Animals exposed to blast-only and radiation-plus-blast demonstrated large increments in venous admixture on the day of insult followed by a major recovery toward baseline values during the first 24 hours following injury. The venous admixture of the blast-only animals approached baseline 7 days after exposure but that of the radiation-plus-blast sheep did not return to baseline until 21 days. The sheep exposed to radiation-only, blast-only, and radiation-plus-blast sustained similar reduction in means carbon monoxide diffusing capacity (DLCO) which were below that of the control mean at 2 days and 7 days post exposure. All of the radiation-only and radiation-plus-blast sheep that survived to or beyond 21 days displayed an overshoot or recovery to their individual baseline DLCO values. The blast-only and radiation-plus-blast animals also exhibited an increased mean ineffective alveolar ventilation (VAIneff) which persisted from 1 to 14 days following the onset of trauma. The radiation-only sheep had an increased VAIneff from 2 through 7 days post exposure. (Author).