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Renin Angiotensin System, Gut-Lung Cross Talk and Microbiota. Lessons from SARS-CoV Infections

Andreia MatosMaria Clara BichoCarolina SantosJoana FerreiraAlda Pereira da SilvaManuel Bicho

出版	2022
主題	Science / Life Sciences / Biochemistry
URL	http://books.google.com.hk/books?id=grEb0AEACAAJ&hl=&source=gbs_api

註釋

The two antagonistic systems of angiotensin converting enzyme (ACE)-1 and ACE-2 are in the ,Äúeye of the hurricane,Äù of severe acute respiratory syndrome coronavirus (SARS-CoV-2). The receptor of the SARS-CoV-2 is the same as ACE-2, which causes its under-expression after binding it, followed by the internalization of the complex virus-ACE-2. ACE-2 have multiple functions with specially relevance in cardiovascular diseases. Furthermore, the non-enzymatic role of ACE-2 gives rise to a Hartnup disease, a phenocopy involving microbiota. With this chapter, we intent to explore the key pathways involved in SARS-CoV-2 infection, from the host perspective, considering our hypothesis related to transporter of neutral amino acids, which includes tryptophan precursor of serotonin and kynurenine.