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IMPACT OF BIS-(BETA-CHLOROETHYL) SULFIDE ON KERATIN PROTEIN AND INTERMEDIATE FILAMENTS IN CULTURED KERATINOCYTES AS INDICATED BY MONOCLONAL ANTIBODY BINDING.

出版	University of MICHIGAN, 1988
URL	http://books.google.com.hk/books?id=iBg-AAAAMAAJ&hl=&source=gbs_api

註釋BCES is a highly toxic alkylating vesicant for human skin. The blister formed at the dermal-epidermal junction, is associated with the necrosis of the basal layer, which appears to be selectively susceptible to BCES. Rat keratinocytes grown in low calcium medium (0.11 mM) form a monolayer culture consisting primarily of a proliferative population, but including cells which exhibit characteristics of differentiated cells. Keratin polypeptides, the major constituent of the intermediate filament systems of