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Follow-up of Implant Survival Comparing Ficoll and Bone Marrow Aspirate Concentrate Methods for Hard Tissue Regeneration with Mesenchymal Stem Cells in Humans

Fabian DuttenhoeferStefan Frank HieberAndres StrickerRainer SchmelzeisenRalf GutwaldSebastian Sauerbier

出版	Universität, 2014
URL	http://books.google.com.hk/books?id=iqYYuAEACAAJ&hl=&source=gbs_api

註釋

Abstract: OBJECTIVE:

Clinical follow-up of implant survival in 11 patients comparing two different methods for mesenchymal stem cell (MSC) isolation (Ficoll and bone marrow aspirate concentrate [BMAC]) applied in maxillary sinus augmentation.


METHODS:

Mononuclear cells, including MSCs, were concentrated with either Ficoll (control group, n=6 sinus) or BMAC (test group, n=12 sinus) and transplanted in combination with bovine bone mineral. A total of 50 implants were placed in a second surgical intervention (17 Ficoll/33 BMAC) and loaded after 4 months. Overall implant survival was assessed with a Kaplan-Meier model using package survival under R.


RESULTS:

Implant survival of the Ficoll group was 100% compared with the BMAC group, which had 93.4% survival (95% confidence interval, 0.849-1). The difference between the groups was not significant (p=0.381).


CONCLUSION:

The BMAC system is an effective and suitable "chair-side" method for clinical application in hard tissue regeneration