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Asymmetric Synthesis Of 3, 3-disubstituted Oxindoles
Renato DalpozzoHelene PellissierSwapandeep Singh ChimniRamon Rios Torres
出版World Scientific, 2019-09-11
主題Science / Chemistry / OrganicMedical / PharmacologyScience / Life Sciences / Biochemistry
ISBN17863473189781786347312
URLhttp://books.google.com.hk/books?id=iu60DwAAQBAJ&hl=&source=gbs_api
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註釋Indole derivatives are the most common heterocycle compounds present in nature, for this reason, they have been referred to as 'privileged structures'. In fact, many approved drugs — and natural products — belong to this family. Among indole derivatives, oxindoles have a structural complexity, which have stimulated generations of synthetic chemists to design strategies for assembling these structures, and their enantioselective synthesis is still growing.This book proposes to describe the known enantioselective syntheses of oxindole derivatives. It is divided in six chapters each referring to a specific class of asymmetric oxindole derivatives. After the introduction, Chapter 2 describes all-carbon spirooxindoles; Chapter 3, open chain 3,3-dialkyloxindoles; Chapter 4, 3-substituted-3-aminooxindoles; Chapter 5, 3-substituted-3-hydroxyoxindoles; Chapter 6, 3-hetero-3-substituted oxindoles. It will be a useful tool for synthetic chemists, who assemble total synthesis of natural products, as well as for drug discovery chemists either in academic or in industry R&S laboratories.