Two Came Running is a depiction of heroism, talent, and geniusall embodied in one family. A war heros prodigious son and daughter cope with multiple tragedies in their youth but rise to prominence on the world scene. Separately they perform vital roles in the struggle against the twentieth century's greatest menace.

Commencing in Chicago and rural Nebraska during the Roaring Twenties and the Great Depression, their journey takes them into the 1930s and 1940s through Hollywood; Washington, DC; and England as WWII rages.