註釋 Introduction: Prevention of depression recurrence is an important goal in the management of depressive patients. The role of nutritional interventions in the management of these patients has not been extensively evaluated.Objectives: To investigate the effectiveness of an extra-virgin olive oil (EVOO)-enriched Mediterranean diet with the improvement of residual depressive symptoms in participants with previous episodes of major depression.Methods: The PREDI-DEP is a multicenter, 2-arms, parallel-group clinical trial with 2 years of intervention. One group of patients is assigned to a Mediterranean diet supplemented with EVOO. The control group has no nutritional intervention. Adherence to the Mediterranean diet is assessed in the intervention group every 3 months through the MEDAS questionnaire (0-14 points). Depressive symptoms are assessed every 4 months in the overall sample using the Beck Depression Inventory (BDI). Generalized Linear Models were used to calculate the adjusted mean changes and their 95% confidence intervals (95% CI) in BDI scores after 4 months of intervention. Results: Adherence to the Mediterranean diet increased in the intervention group (baseline MEDAS score=median: 7; p25-p50: 6-8; 3-months MEDAS score= median: 9; p25-p50: 8-10; p 