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ENHANZE® Drug Delivery Technology
其他書名
Advancing Subcutaneous Drug Delivery using Recombinant Human Hyaluronidase PH20
出版Karger Medical and Scientific Publishers, 2022-06-30
主題Medical / PharmacologyMedical / Clinical Medicine
ISBN33180707699783318070767
URLhttp://books.google.com.hk/books?id=mG13EAAAQBAJ&hl=&source=gbs_api
EBookSAMPLE
註釋

‘ENHANZE® drug delivery technology: Advancing subcutaneous drug delivery using recombinant human hyaluronidase PH20’ provides readers with in-depth information on the potential benefits and challenges of subcutaneous (SC) drug delivery, the biology of hyaluronan and hyaluronidases in the SC space, and a comprehensive overview on the history of hyaluronidases and the development of recombinant human hyaluronidase PH20 (rHuPH20). 

Current applications of rHuPH20 as well as approved biotherapeutics utilizing HuPH20-facilitated SC drug delivery are summarized, and the underlying non-clinical and clinical development approaches are introduced as a basis for future application to biologics in various disease areas.


Table of Contents:


• Introduction to subcutaneous drug delivery

• Biology of hyaluronan and hyaluronidases in the subcutaneous space

• History of hyaluronidases and development of rHuPH20

• The ENHANZE® platform: Clinical applications of a subcutaneous drug delivery technology

• Application of ENHANZE® drug delivery technology: Development of currently marketed products