‘ENHANZE® drug delivery technology: Advancing subcutaneous drug delivery using recombinant human hyaluronidase PH20’ provides readers with in-depth information on the potential benefits and challenges of subcutaneous (SC) drug delivery, the biology of hyaluronan and hyaluronidases in the SC space, and a comprehensive overview on the history of hyaluronidases and the development of recombinant human hyaluronidase PH20 (rHuPH20).
Current applications of rHuPH20 as well as approved biotherapeutics utilizing HuPH20-facilitated SC drug delivery are summarized, and the underlying non-clinical and clinical development approaches are introduced as a basis for future application to biologics in various disease areas.
Table of Contents:
• Introduction to subcutaneous drug delivery
• Biology of hyaluronan and hyaluronidases in the subcutaneous space
• History of hyaluronidases and development of rHuPH20
• The ENHANZE® platform: Clinical applications of a subcutaneous drug delivery technology
• Application of ENHANZE® drug delivery technology: Development of currently marketed products