登入選單

返回Google圖書搜尋

Graphic Network Based Methods in Discovering TFBS Motifs

Lizhi Li

出版	Ohio State University, 2012
URL	http://books.google.com.hk/books?id=ml9LnQAACAAJ&hl=&source=gbs_api

註釋

Abstract: To find motifs of transcriptional factors binding sites (TFBS) is essential to understand many biological processes in a cell. Currently the algorithms in discovering the motifs can be divided into three categories: word numeration methods, probabilistic based methods and newly developed graphic network based methods. Graphic network based methods show their advantages over the other two categories of algorithms on prediction accuracy, sensitivity and specificity. This thesis gives a comprehensive overview the main motif discovery methods which are being used now and especially, focuses on the introduction of graphic network based methods. In addition, a study in discovering the TFBS motifs of E2F1, which is a well-known transcription factor, is performed by applying graphic network based algorithms.