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Skin Carcinogenesis; Mechanisms and Human Relevance (Volume 298).

出版	1989
URL	http://books.google.com.hk/books?id=op_YswEACAAJ&hl=&source=gbs_api

註釋Model systems for defining initiation, promotion, and progression of skin neoplasms; Relevance for man of skin carcinogenicity in experimental animals; Human model systems for studies of skin cancer; The role of papillomaviruses in human and animal epithelial neoplasia; Morphological evaluation of the effects of carcinogens and promoters; Epidermal tumor promotion by damage in the skin of mice; Mouse skin papillomas as a stage in cancer progression; Malignant conversion, the first stage in progression from benign to malignant tumors; Relevance of in vitro transformation systems to skin carcinogenesis in vivo; Human epidermal keratinocyte cell culture and xenograft systems, application in the detection of potential chemical carcinogens and the study of epidermal transformation; Consequences of exposure to initiating levels of carcinogens in vitro and in vivo, altered differentiation and growth, mutations, and transformation; Initiation of skin carcinogenesis can occur by induction of carcinogen specific point mutations in the Harvey ras gene; Differential gene expression in skin tumors initiated by ionizing radiation or chemical carcinogens; Metabolism of polycyclic aromatic hydrocarbons and phorbol esters by mouse skin, relevance to mechanism of action and trans-species/strain carcinogenesis; The protein kinase C pathway in tumor promotion; Regulation of ornithine decarboxylase in normal and neoplastic mouse and human epidermis; Role of free radicals in tumor promotion and progression; The arachidonic acid cascade and multistage carcinogenesis in mouse skin; Short term assays to detect tumor promoting activity of environmental chemicals; Diversity in the chemical nature and mechanism of response to tumor promoters; Developing design standards for dermal initiation/promotion screening studies; Prospective assessment of human carcinogens, the determination of genotoxic action in human skin; Mechanistic studies of tobacco carcinogenesis in mouse epidermis and lung tissues; Mouse skin tumors as predictors of human lung cancer for complex emissions, an overview; Experience gained by the petroleum industry in the conduct of dermal carcinogenesis bioassays; Skin carcinogenicity bioassays of petroleum refinery streams, issues of interpretation; Application of short term assays by the petroleum industry to identify skin carcinogens.