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Reaction Engineering Characterization of Biocatalytic Organoborane Synthesis

Jens Hennig

出版	Technische Universität Hamburg, 2023
URL	http://books.google.com.hk/books?id=oviC0AEACAAJ&hl=&source=gbs_api

註釋

Organoboranes (OBs) are versatile building blocks and precursors for various applications in todays agriculture, pharmacy and organic chemistry. To replace their environmentally offensive and less-selective chemical synthesis routes, this thesis focused on a recently discovered biocatalytic approach of OB synthesis called biocatalytic borylation. Here, tests investigated the state of the starting materials with respect to pH, temperature and UV-light. The enzymatic reaction was characterized according to Michaelis-Menten kinetics to derive a kinetic model, which was evaluated via simulations. Moreover, OB synthesis was executed in batch, fed-batch and continuous mode, where especially the fed-batch mode improved space-time yield and the final product concentration.