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The Radioprotective Effect of Mixtures of AET and Serotonin
E. G. SanderMarilyn George
出版Aerospace Medical Laboratory, Aeronautical Systems Division, Air Force Systems Command, United States Air Force, 1961
URLhttp://books.google.com.hk/books?id=rXZ286d4uj8C&hl=&source=gbs_api
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註釋Experiments were conducted to determine the protection provided the erythropoietic system of rats against whole-body, gamma radiation by mixtures of AET (2-aminoethyl-isothiouronium bromide) and serotonin (5-hydroxytryptamine). The incorporation of iron-59 (Fe-59) into newly formed red blood cells was used as the criterion of the radioprotection afforded. Two concentrations of AET plus serotonin (40 microliters AET, 20 microliters serotonin and 20 microliters AET, 10 microliters serotonin) offered initial protection against the depression of the erythropoietic rate associated with radiation exposure. The higher concentration of this mixture produced mortality due to toxicity of the compounds. AET and serotonin mixtures did not alter the initial radiation-induced leucopenia. However, the protected rats had higher white blood cell counts 18 days after radiation exposure. Daily gains in body weight appeared somewhat greater in the rats injected with AET and serotonin than the nonprotected, irradiated animals.