登入
選單
返回
Google圖書搜尋
CEDAR, an Online Resource for the Reporting and Exploration of Complexome Profiling Data
Joeri van Strien
Alexander Haupt
Uwe Schulte
Hans-Peter Braun
Alfredo Cabrera-Orefice
Jyoti S Choudhary
Felix Evers
Erika Fernandez-Vizarra
Sergio Guerrero-Castillo
Taco W. A. Kooij
Petra Páleníková
Mercedes Pardo
Cristina Ugalde
Ilka Wittig
Lars Wöhlbrand
Ulrich Brandt
Susanne Arnold
Martijn A. Huynen
出版
Universität
, 2021
URL
http://books.google.com.hk/books?id=r_l8zgEACAAJ&hl=&source=gbs_api
註釋
Abstract: Complexome profiling is an emerging 'omics' approach that systematically interrogates the composition of protein complexes (the complexome) of a sample, by combining biochemical separation of native protein complexes with mass-spectrometry based quantitation proteomics. The resulting fractionation profiles hold comprehensive information on the abundance and composition of the complexome, and have a high potential for reuse by experimental and computational researchers. However, the lack of a central resource that provides access to these data, reported with adequate descriptions and an analysis tool, has limited their reuse. Therefore, we established the ComplexomE profiling DAta Resource (CEDAR, www3.cmbi.umcn.nl/cedar/), an openly accessible database for depositing and exploring mass spectrometry data from complexome profiling studies. Compatibility and reusability of the data is ensured by a standardized data and reporting format containing the "minimum information required for a complexome profiling experiment" (MIACE). The data can be accessed through a user-friendly web interface, as well as programmatically using the REST API portal. Additionally, all complexome profiles available on CEDAR can be inspected directly on the website with the profile viewer tool that allows the detection of correlated profiles and inference of potential complexes. In conclusion, CEDAR is a unique, growing and invaluable resource for the study of protein complex composition and dynamics across biological systems