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Determinants of Total and High Density Lipoprotein Cholesterol in Boys and Men with Special Reference to Diet
註釋Chapter 6 contains a general discussion of the various studies. The main conclusions were the following:- young boys from countries like Finland, the Netherlands, Denmark, Austria and Sweden are likely to be at a higher risk of developing coronary heart disease than boys from Greece or Portugal and boys from Asian and African countries;- the negative relationship between HDL cholesterol concentration and mortality or incidence from coronary heart disease as found within populations is not incompatible with the absence of a negative or even the presence of a positive relationship between HDL cholesterol and mortality from coronary heart disease when different countries are compared;- the changes induced by diet in the concentrations of total and HDL cholesterol tend to be parallel;- high concentrations of HDL cholesterol associated with a high intake of animal fat probably reflect a higher capacity to handle large amounts of dietary fat;- low concentrations of HDL cholesterol associated with a high intake of animal fat probably reflect a lower capacity to handle large amounts of dietary fat or when associated with a low intake of fat a normal capacity to handle dietary fat;- diets with relatively high proportions of food from vegetable origin, especially those relatively rich in complex carbohydrates and relatively poor in saturated fat, together with a considerable proportion of physical activity and an optimum level of body fatness might be beneficial for the prevention of the development of atherosclerosis in childhood.