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The Role of Valpha14-invariant NKT Cells in the Induction of TH2 Airway Inflammation

出版	University of Chicago, 2010
ISBN	11240493479781124049342
URL	http://books.google.com.hk/books?id=tLtSAQAACAAJ&hl=&source=gbs_api

註釋I determined that the activation of Valpha14-iNKT cells in the lung results in the generation of TH2 but not TH1 cells. This activation results in the production of large quantities of chemokines as well as TH1, TH2 and TH-17 and regulatory cytokines in the airways within the first week after sensitization. This cytokine storm, however, resolves as a TH2 response as demonstrated post challenge. It was determined using knockout mice that IL4 and IL4Ra, but not IFN-g and IL-10, are required for this response. Using conditional CD1d knockout mice, I determined that while CD1d presentation by B cells, granulocytes and alveolar macrophages is not required for an eosinopillic response, presentation by dendritic cells is necessary for the generation of eosinophilia. Furthermore, using mixed bone marrow chimeras, in which CD1d knockout mice were reconstituted with a mixture of CD1d knockout and Class II knockout cells, I found that the same dendritic cell must present lipid to both the activated Valpha14-iNKT cell and peptide to a naive ovalbumin-specific T cell to properly generate an eosinophillic response.