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Association of Secreted Frizzled-related Protein 4 (SFRP4) with Type 2 Diabetes in Patients with Stable Coronary Artery Disease

Michael Marcus HoffmannChristian WernerMichael BöhmKarl Winkler

出版	Universität, 2014
URL	http://books.google.com.hk/books?id=tYuDswEACAAJ&hl=&source=gbs_api

註釋Abstract: Background:Secreted frizzled-related proteins (SFRP) are regulators of Wnt-signalling. SFRP4 has been shown to regulate insulin exocytosis and is overexpressed in type 2 diabetes mellitus. Here we characterized the relation of SFRP4 to glucose and triglyceride metabolism and outcomes in patients with stable coronary artery disease on statin treatment in the prospective Homburg Cream & Sugar Study (NCT00628524).Methods:Fasting SFRP4 concentrations were measured by ELISA in 504 consecutive patients with stable CAD confirmed by angiography. Results:The median age was 68 years and 83% of patients were male. Oral glucose tolerance tests were performed in all patients without known diabetes for metabolic characterization. 24.4% of patients showed normal glucose tolerance, 29.4% impaired glucose tolerance and 46.2% diabetes mellitus. SFRP4 concentrations correlated with insulin (R = 0.153, p = 0.001), HbA1c (R = 0.166, p