This book is a reflection on contemporary computational design thinking at the intersection of architecture, urban design, and landscape architecture, in a time marked by complex challenges like climate change, urbanization and population growth. Based on a critical rethinking of the notion of ground and the relation between the manmade and the natural environment, an understanding of architecture as regenerative practice is proposed. It aims at a built environment as landscape, at an architecture of prosthetic nature. The design approach is illustrated by a number of design experiments conducted within a studio setting and complemented by a series of conversations with leading experts on sustainable design and landscape architecture.