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Exploring the Effects of Diet on Autotaxin-transgenic FVB/N Mice and Abnormalities in the Night Time Bouts of FVB/N Mice
註釋This study explores some of the effects of a matched high-fat, low-carbohydrate diet versus a low-fat, high-carbohydrate diet on FVB/NJ autotaxin transgenic mice. This study observed abnormal behavior among the leaner mice and explains the rationale behind that observation. The in vivo diet study was set up to explore how autotaxin induced obesity impacts the development of cancer. Throughout the course of this study, the male mice on a low-fat, high-carbohydrate diet exhibited signs of stress or aggression towards their littermates, resulting in an abnormal amount of cage separations. From this study, it was concluded that the night time bouts that were observed were caused by the higher available energy to the lean mice, meaning they simply had too much energy and not enough space to avoid clashing with each other, and no opportunity to escape or avoid physical confrontations.