Cancer is a multifaceted disease in which genetic changes induce uncontrolled tumor growth. Genomic characterization of cancer is now leading to better diagnostic, prognostic and predictive biomarkers, and effective individualized management. 'Fast Facts: Comprehensive Genomic Profiling' provides a crash course in the science, methods and application of genomic profiling. Assuming only the most basic knowledge – or memory – of cell biology, the authors provide an overview of DNA and RNA biology and next-generation sequencing. This sets in context the descriptions of prognostic and predictive biomarkers for different cancer types and genomic-based treatments. Finally, but importantly, some of the practicalities of gaining and interpreting genomic information are described. 

Whether you need a primer or a refresher, this short colorful book demystifies this complex subject.

Contents:

• Genetic mutations and biomarkers

• Understanding next-generation sequencing

• Elements of comprehensive genomic profiles

• Role in precision oncology

• Predictive and prognostic biomarkers

• Overcoming barriers to genotype-directed therapy