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The Innate Immune Response to House Dust Mite in Allergic Airway Inflammation

Madelyn Hope Miller

出版	University of Central Florida, 2020
URL	http://books.google.com.hk/books?id=uoRGzgEACAAJ&hl=&source=gbs_api

註釋

Using knock-out mice, we have shown that the kinase RIP2, which functions downstream of the peptidoglycan receptor NOD2, is involved in the early response to HDM likely within AECs and that its activation promotes airway inflammation. In follow-up work, we also demonstrate that early and acute pharmacologic inhibition of this kinase in a HDM asthma model has lasting effects on the reduction of airway inflammation and type 2 immunity associated with the pathology. The third project describes the identification of a novel receptor for HDM, LMAN1. We find that LMAN1 on dendritic cells functions to inhibit inflammatory responses to HDM and that loss of LMAN1 enhances airway inflammation in an asthma model. Altogether, my work has contributed to our understanding of the early events and molecules involved in responding to HDM. Our hope is that these findings will be useful in the discovery and testing of new therapies for treatment of allergic disease.