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Drug Safety Evaluation
Shayne Cox Gad
出版John Wiley & Sons, 2016-12-01
主題Medical / PharmacologyMedical / BiotechnologyScience / Chemistry / ToxicologyScience / Chemistry / General
ISBN111909741X9781119097419
URLhttp://books.google.com.hk/books?id=vhyjDQAAQBAJ&hl=&source=gbs_api
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註釋This practical guide presents a road map for safety assessment as an integral part of the development of new drugs and therapeutics.
  • Helps readers solve scientific, technical, and regulatory issues in preclinical safety assessment and early clinical drug development
  • Explains scientific and philosophical bases for evaluation of specific concerns – including local tissue tolerance, target organ toxicity and carcinogenicity, developmental toxicity, immunogenicity, and immunotoxicity
  • Covers the development of new small and large molecules, generics, 505(b)(2) route NDAs, and biosimilars
  • Revises material to reflect new drug products (small synthetic, large proteins and cells, and tissues), harmonized global and national regulations, and new technologies for safety evaluation
  • Adds almost 20% new and thoroughly updates existing content from the last edition