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Hippocampal Low-frequency Stimulation Prevents Seizure Generation in a Mouse Model of Mesial Temporal Lobe Epilepsy
Enya Paschen
Claudio Elgueta
Katharina Heining
Diego M. Vieira
Piret Kleis
Catarina Reis Orcinha
Ute Häussler
Marlene Bartos
Ulrich Egert
Philipp Janz
Carola Haas
出版
Universität
, 2020
URL
http://books.google.com.hk/books?id=viBGzgEACAAJ&hl=&source=gbs_api
註釋
Abstract: Mesial temporal lobe epilepsy (MTLE) is the most common form of focal, pharmacoresistant epilepsy in adults and is often associated with hippocampal sclerosis. Here, we established the efficacy of optogenetic and electrical low-frequency stimulation (LFS) in interfering with seizure generation in a mouse model of MTLE. Specifically, we applied LFS in the sclerotic hippocampus to study the effects on spontaneous subclinical and evoked generalized seizures. We found that stimulation at 1 Hz for one hour resulted in an almost complete suppression of spontaneous seizures in both hippocampi. This seizure-suppressive action during daily stimulation remained stable over several weeks. Furthermore, LFS for 30 min before a pro-convulsive stimulus successfully prevented seizure generalization. Finally, acute slice experiments revealed a reduced efficacy of perforant path transmission onto granule cells upon LFS. Taken together, our results suggest that hippocampal LFS constitutes a promising approach for seizure control in MTLE