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Prognostic Impact and Diagnostic Value of Invasively Derived Hemodynamic Measures in Patients with Severe Aortic Stenosis Undergoing TAVI

David GrundmannAlina GoßlingLennard SchmidtLisa VoigtlaenderSebastian LudwigMatthias LinderLara WaldschmidtTill Joscha DemalOliver Daniel BhadraAndreas SchaeferHermann ReichenspurnerStefan BlankenbergLenard ConradiDirk WestermannMoritz SeiffertNiklas Schofer

出版	Universität, 2023
URL	http://books.google.com.hk/books?id=wS0H0AEACAAJ&hl=&source=gbs_api

註釋Abstract: Background
Ejection time (ET), acceleration time (AT) and time between left ventricular and aortic systolic pressure peaks (T-LVAo) might be of diagnostic and prognostic use in patients with aortic stenosis (AS) undergoing transcatheter aortic valve implantation (TAVI).

Aim
We aimed to assess the diagnostic value and prognostic impact of invasively measured ET, AT, and T-LVAo in patients undergoing TAVI.

Methods
A total of 1274 patients received invasive measurement of ET, AT and T-LVAo prior to TAVI. Anatomic AS severity was assessed by CT-derived aortic valve calcification density (AVCd). Impact on all-cause mortality was retrospectively analyzed.

Results
In multivariable linear regression, T-LVAo showed the strongest correlation with AVCd. No prognostic impact of T-LVAo was found according to uni- and multivariable analyses. In contrast, using an individual C-statistic derived cutoff (CD), patients with ET or AT ≥ CD showed lower mortality rates compared to patients with ET or AT CD (1-year mortality: ET ≥ vs. CD: 15.01vs. 33.1%, AT ≥ vs CD 16.3 vs. 26.5%, p