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Chapter 15. Animal Models of Cholestasis
出版Elsevier Inc. Chapters, 2013-05-29
主題Medical / GeneralScience / Life Sciences / Zoology / GeneralScience / Life Sciences / BiologyMedical / Laboratory MedicineScience / Life Sciences / GeneralScience / Life Sciences / Anatomy & PhysiologyMedical / Internal Medicine
ISBN01280720599780128072059
URLhttp://books.google.com.hk/books?id=xJpzDAAAQBAJ&hl=&source=gbs_api
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註釋Cholestatic liver diseases, such as primary sclerosing cholangitis (PSC) and primary biliary cirrhosis (PBC), represent an important group of liver diseases of the intra- and extrahepatic bile ducts frequently causing end-stage liver disease with significant morbidity and mortality due to limited treatment options. The limitations of the currently available medical therapy largely reflect our deficits in understanding the pathophysiology of cholestatic liver diseases. Therefore, there is an urgent need for reliable, well-defined and easily reproducible animal models to gain insights into the PSC and PBC pathophysiology and to test novel treatment modalities. We aimed to provide a systematic overview of currently available animal models for sclerosing cholangitis and biliary fibrosis and critically discuss the characteristics of rodent models for PSC and PBC, models of experimental biliary obstruction, models of inflammation-induced cholestasis, as well as models of inherited cholestatic syndromes.