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The Chemistry and Pharmacology of Certain Compounds Affecting the Central Nervous System of Animals and Man
註釋The extensive actions of tetrahydrocannabinol derivatives upon the cardiovascular system suggest that these agents act by inhibition of the afferent to efferent areas of the central components of the sympathetic nervous system. Behavioral changes characterized by CNS depression, ataxia, analgesia and enhanced tendon reflexes have been described. The general toxicity of the tetrahydrocannabinol derivatives is discussed as well as the effects of drugs which antagonize or potentiate their pharmacological actions. An analysis of structure activity relationship is presented for the tetrahydrocannabinol derivatives evaluated in this study.