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THE DEVELOPMENT OF MULTIFUNCTIONAL PROTEIN CROSS-LINKING REAGENTS BASED UPON CITRACONIMIDE AND CITRACONIC ANHYDRIDE DERIVATIVES.

ANDREA CHRISTINE DUPONT

出版	University of MICHIGAN, 1986
URL	http://books.google.com.hk/books?id=ycWHHAAACAAJ&hl=&source=gbs_api

註釋

A series of reagents have been developed which can interact with nucleophilic sulfhydryl groups on proteins by a consecutive sequence of Michael reactions to form intra- and intermolecular cross-linked structures. These reagents are derivatives of citraconimide having spectroscopic probe residues on the imide nitrogen and water soluble or spectroscopically active leaving groups at the 4-position. These absorbant and fluorescent functions allow the monitoring of the progress of the cross-linking reaction