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Use of Sublingual Fentanyl in Postoperative Pain Management

出版	2017
URL	http://books.google.com.hk/books?id=zhC2zQEACAAJ&hl=&source=gbs_api

註釋Background-AimUse of sublingual fentanyl is not an established method for acute postoperative pain management. Fentanyl is used though epidurally in such conditions. Goal of this prospective clinical study is to demonstrate sublingual fentanyl use in this setting.Material-MethodsWe studied patients who underwent major surgical procedures, had no epidural catheter, their postoperative analgesic treatment was arranged by their surgeons, and anaesthesiologists were asked to manage their acute pain when their pain treatment was insufficient and they expressed severe pain (>7 VAS score). They have been administered either morphine, tramadol, pethidine iv or sublingual fentanyl. Complicaions such as nausea, vomiting, respiratory depression, and oxygen desaturation were recorded.Results420 patients who were asked for rescue postoperative pain management (VAS score>7), since their originally administered analgesia was inadequate, were randomly assigned to four groups of 105 (group A: morphine 0.1mg/kg, group B: pethidine 0.5mg/kg, group C: tramadol 50mg iv in N/S 100ml in 15min and group D:sublingual fentanyl 67u03bcg). Onset of action, pain relief and side effects were recorded in all groups. Group D patients a significantly faster onset of action [6u00b12,1min, (p