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Proprotein Convertases in Gynecological Cancers

Daniel Bassi

出版	Morgan & Claypool Publishers, 2012
ISBN	16150446479781615044641
URL	http://books.google.com.hk/books?id=zhp62m1j-LIC&hl=&source=gbs_api
EBook	SAMPLE

註釋

Gynecological cancers include neoplasias of internal female genital organs, mainly ovarian, endometrial and cervical tumors, and cancers of the external female genital structures. Current scientific evidence indicates that both up- and down-regulation of the expression of PCs are part of the multiple changes occurring in these gynecological tumors. Nevertheless, the physiological significance of this puzzling pattern of PC expression remains elusive. The fact that PCs can activate both pro- and anticarcinogenic substrates may indicate that the nature of the overexpressed substrates in certain cancer types could determine the final outcome; i.e., slowing or accelerating cancer development.