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Intraoperative Frozen Section Could be Misleading in the Diagnostic Evaluation of Ovarian Granulosa Cell Tumors

出版	2017
URL	http://books.google.com.hk/books?id=9X2yzQEACAAJ&hl=&source=gbs_api

註釋Intraoperative frozen section could be misleading in the diagnostic evaluation of ovarian granulosa cell tumors.OBJECTIVE: We aimed to determine the value of intraoperative frozen section (FS) and ultrasound in the diagnosis of ovarian granulosa cell tumors.MATERIALS AND METHODS: Data of 20 patients with granulosa cell tumors underwent ovarian frozen section, between June 2006 and March 2019, during the surgical procedure were retrospective reviewed. The ultrasound imaging and intra-operative frozen section results were compared with the definitive surgical diagnosis. Surgical data were reviewed and analyzed. RESULTS: A total of 12 cases were correctly identified at the intraoperative FS as ovarian granulosa tumors. There were 8 (32%) false negative diagnoses. Preoperatively, all 20 cases were correctly suspected as ovarian granulosa cell tumors. About surgical treatment, in 12 women with positive FS an appropriate surgical staging was performed. In 8 women with negative FS, regardless the previous ultrasound suspicious, surgical treatment was variable: 4 women underwent laparoscopic annessiectomy and surgical staging was completed after definitive surgical diagnosis; hysterectomy and bilateral annessiectomy was performed in 2 patients; the conservative surgery on the healthy ovary was performed in the remaining 2 patients.CONCLUSION: This study concluded that FS appears to be an inadequate technique for the histopathological diagnosis of ovarian granulosa cell tumors, while the US features are really suggestive allowing a right clinical suspicious. Perhaps, when the suspicious of ovarian granulosa cell tumors is strong at the US, intraoperative FS could be misleading and could lead to a wrong surgical management.