The 4th volume of the journal "Engineering Innovations" contains articles devoted to research results in machine and equipment design and some issues in biomedical engineering, such as the 3D printing of unique scaffolds for drug delivery and health informatics. There also are finite element analysis of damage of the cylindrical roller bearing of shot blasting machine, the development of the method for enhancing the energy efficiency of the heat exchanger, vibration analysis of mini unmanned aerial vehicle and some examples of the computational design of technological equipment. Engineers, technologists, academics, and students will appreciate the presented articles.