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Kainic Acid
Sumit Sahkar
James Raymick
Dushyant Mann
John F. Bowyer
Larry C. Schmued
Srinivasulu Chigurupati
Elena Marusich (Ph.D.)
Jean-Pierre Louboutin (M.D., Ph.D.)
David S. Strayer (M.D., Ph.D.)
Nandeo Choony
Lisa James
Courtney Rabun
Sushil Sharma
Mzia G. Zhvania
Tamar G. Lordkipanidze
Maia Kiladze
Nadezhda J. Japaridze
Nato Kotaria
Tamar Z. Bikashvili
Musa V. Mabandla
Lihle Qulu
其他書名
Neurotoxic Properties, Biological Sources and Clinical Applications
出版
Nova Science Publishers, Incorporated
, 2014
主題
Medical / Biochemistry
Science / Life Sciences / Biochemistry
Science / Chemistry / Organic
ISBN
1631179128
9781631179129
URL
http://books.google.com.hk/books?id=usx_oAEACAAJ&hl=&source=gbs_api
註釋
Kainic acid is a naturally occurring amino acid that is isolated from red algae and is known to cause amnesic shellfish poisoning via the activation of AMPA and kainate receptors in the hippocampus. Kainic acid is an analogue of glutamate and can modulate the transmission of glutamate. It's neurotoxic potency has been shown to be 30 fold that of glutamate. Glutamate is an excitatory neurotransmitter that exerts its postsynaptic effects through ionotropic and metabotropic receptors. Of the ionotropic glutamate receptors (GluRs), kainic acid has a high affinity for 5 subtypes (KA1 and KA2, GluR5, GluR6, GluR7). Kainate receptors play a significant role in the physiological functioning and activity of numerous systems in the brain. This book discusses the neurotoxic properties of kainic acid, as well as the biological sources and clinical applications.
